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Literature summary extracted from

  • Bruender, N.A.; Young, A.P.; Bandarian, V.
    Chemical and biological reduction of the radical SAM enzyme 7-carboxy-7-deazaguanine synthase (2015), Biochemistry, 54, 2903-2910 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.3.99.3
-
 Bacillus subtilis

Organism

EC Number Organism UniProt Comment Textmining
4.3.99.3 Bacillus subtilis O31677
-
-
4.3.99.3 Bacillus subtilis 168 O31677
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.3.99.3
-
 Bacillus subtilis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.3.99.3 6-carboxy-5,6,7,8-tetrahydropterin
-
 Bacillus subtilis 7-carboxy-7-carbaguanine + NH3
-
 ?
4.3.99.3 6-carboxy-5,6,7,8-tetrahydropterin
-
 Bacillus subtilis 168 7-carboxy-7-carbaguanine + NH3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.3.99.3 BsQueE
-
 Bacillus subtilis
4.3.99.3 CDG synthase
-
 Bacillus subtilis

Cofactor

EC Number Cofactor Comment Organism Structure
4.3.99.3 4Fe-4S-center the enzyme requires the one electron reduction of the [4Fe-4S]2+ cluster to the +1 oxidation state. This can be achieved by using a chemical reductant, such as dithionite, or a biological reducing system in which the reducing equivalents are derived from NADPH and transferred to the cluster via flavodoxin reductase and flavodoxin Bacillus subtilis
4.3.99.3 S-adenosyl-L-methionine S-adenosyl-L-methionine-dependent radical enzyme Bacillus subtilis